OsteoDx’s Cortical Bone Mechanics Technology™ Products for Scientific Research
The mission of the OsteoDx Instrument Division is to open opportunities for scientists to investigate the mechanical integrity of cortical bone in living human subjects.
OsteoDx instruments perform dynamic mechanical bending tests on forearms of living people. Proprietary Cortical Bone Mechanics Technology™ (CBMT) in AEIOU Scientific Instruments:
- Applies oscillatory forces via a blunt probe to the skin overlying the ulna bone in the forearm,
- Measures the resulting oscillatory acceleration of the probe, analyzes these force and acceleration signals to measure ulna bending mass (m), stiffness (k), and damping (d), and
- Calculates the quality factor (Q), flexural rigidity (EI) and bending strength (Mpeak) of ulnar cortical bone
CBMT Model SI-001
Noninvasive CBMT measurements of ulna EI has been validated by Quasistatic Mechanical Testing (QMT) of flexural rigidity (EI) and bending strength (Peak Moment before fracture) in 35 cadaveric arms from men and women ranging widely in age (17<Age<99 yrs) and body size (14<BMI<40 kg/m2). †
† Bowman et al. A new noninvasive mechanical bending test accurately predicts ulna bending strength in cadaveric human arms. Bone (submitted).
The OsteoDx instrument is intended for use by scientists in life science investigations of the mechanical integrity cortical bone in the ulna. Such investigations include:
Observational studies comparing cortical bone mechanics in demographic groups and monitoring changes in cortical bone mechanics over time; and
Experimental studies investigating local effects of mechanical loading (i.e., exercise) and systemic effects of nutrition, hormonal, nutraceutical and pharmaceutical agents on cortical bone mechanics.